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Featured Products

We’re currently featuring SkinMedica’s TNS line, containing a stabilized growth factor blend that helps improve the appearance of fine lines, wrinkles, skin tone and texture.

TNS Essential Serum

TNS Essential Serum

All-in-one skin rejuvenating treatment improves the appearance of fine lines, wrinkles, skin tone and texture.

This unparalleled anti-aging serum is the first to combine the renowned growth factor serum, TNS Recovery Complex in one chamber and APS Corrective Complex™, a potent mixture of antioxidants, peptides and other innovative anti-aging ingredients, in the other chamber. Together these products work synergistically to transform and regenerate your skin for a more youthful appearance.

Key Benefits
  • Reduced appearance of wrinkles
  • Enhanced skin texture and tone
  • Initial results occurred in 30 days with optimal results occurring in 90 days
Key Ingredients

Human Fibroblast Conditioned Media – A growth factor which capitalizes on the physiological advantage of many tissue factors in one solution that interact. Dipalmitoyl Hydroxyproline – A plant-derived amino acid with multifunctional anti-aging activities that promote the production of Tissue Inhibitors of Metalloproteinase (TIMPs) which are able to suppress the synthesis of Matrix Metalloproteinases (MMPs), enzymes involved in extracellular matrix degradation.

Palmitoyl Tripeptide-5 – Has a unique peptide sequence that mimics the body’s own mechanism to activate Tissue Growth Factor (TGF-beta), known as the key element in the synthesis of collagen.

Hydrolyzed Silk, Phospholipids, Butylene Glycol and Water – A combination of silk peptides encapsulated in liposomes that assimilate with skin cells to stimulate production of hyaluronic acid and collagen to improve skin tone and texture. Inhibits tyrosinase activity to reduce uneven skin pigmentation.

Ergothioneine (EGT) – A natural amino acid with super-antioxidant properties that protect cells against oxidative damage by scavenging reactive oxygen species, reducing UV-induced hydrogen peroxide, suppressing the expression of MMP-1 (proteins involved in the breakdown of extracellular matrix), and reducing inflammation.

Ubiquinone (Coenzyme Q10) – Effectively counteracts free radical damage and provides significant protection against UVA-induced detrimental effects of photoaging. Coenzyme Q10 works synergistically with vitamin E in preventing damage to lipid membranes and plasma lipids.

Tetrahexyldecyl Ascorbate – A stable, lipid-soluble ester form of ascorbic acid (vitamin C), a free radical scavenger that fights aging symptoms in the skin while enhancing collagen production for firmer skin. Helps reduce the appearance of hyperpigmentation and age spots.

Tocopheryl Acetate – Stabilized ester of vitamin E that is considered the most important antioxidant and free radical scavenger. Moisturizes the skin from within, improving smoothness.

Camellia Sinensis (Green Tea) Leaf Extract – Reduces redness and suppresses skin inflammation and irritation while providing powerful antioxidant properties that help protect cells from free radical damage initiated by environmental factors.

Rubus Fruticosus (Blackberry) Leaf Extract – A plant derived inhibitor of Matrix Metalloproteinases (MMPs) that prevents the degradation of the extracellular matrix thereby helping to prevent wrinkle formation. The extract also exhibits antioxidant activity which helps fight the visible signs of aging.

Saccharomyces Ferment Filtrate Lysate – A yeast extract that when topically applied defends against the detrimental effect of ozone (which has an ability to deplete antioxidants in the skin), and improve the barrier function of the skin.

Aminobutyric Acid – When administered systemically, it functions as neuromuscular inhibitor which reduces excitability of the nerves and produces muscle relaxation.

Hyaluronic Filling Spheres – Dehydrated filling spheres penetrate into skin folds of varying depth and trap water in the superficial layers of the skin. The remarkable characteristic of hyaluronic acid that acts as a molecular sponge, enables the spheres to swell and exert pressure in the direction of the surface, resulting in a smoothing effect on the skin.

Alpha-Arbutin – An extract from Bearberry plant that provides a lightening effect on the skin by inhibiting tyrosinase activity (the enzyme responsible for skin pigmentation).

$ 285.00

Regular price 
TNS Illuminating Eye Cream

TNS Illuminating Eye Cream

Reduces the appearance of fine lines, wrinkles and dark circles around the eyes and improves skin tone and texture.

TNS Illuminating Eye Cream not only includes TNS® to improve the appearance of fine lines, wrinkles, skin tone and texture, but it also contains peptides to help support the skin around the eyes. Additionally this product has unique ingredients to help improve the appearance of dark circles.

Key Ingredients

Human Fibroblast Conditioned Media (TNS®): A physiologically balanced, naturally secreted and stabilized combination of multiple natural messenger proteins.

Hydroxysuccinimide and Chrysin: This combination of ingredients reduces the appearance of dark circles.

Boron Nitride: Optimizes the optical diffusion effect of light, which lessens the visibility of dark circles and discolorations to enhance skin appearance.

$ 88.00

Regular price 
TNS Recovery Complex

TNS Recovery Complex

Clinically shown to reduce the appearance of skin discoloration and improve the appearance of fine lines and wrinkles.

SkinMedica TNS Recovery Complex contains proteins, amino acids and antioxidants that the body uses in its own natural repairing process. This produces an incredibly gentle solution in the fight against sun damage and aging. No more harsh chemicals disturbing the skin! Other natural ingredients repair blood vessels, reduce inflammation and encourage cell growth. TNS will help improve the appearance of the skin, shrink fine lines and wrinkles and cast a healthy, youthful glow on the skin.

Key Ingredient

Human Fibroblast Conditioned Media (TNS®): A physiologically balanced, naturally secreted and stabilized combination of multiple natural messenger proteins.

$ 190.00

Regular price 

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About Z Skin

About Our Store
About Dr. Zanelli
About The Dermatology Center

The Z Skin Online store contains a carefully-curated selection of products that Dr. Zanelli, one of the Bay Area's premier board certified dermatologists, has found to be effective in clinical practice. Our focus is on quality and value, and we offer products from trusted brands such as SkinMedica and EltaMD as well as private-label Z Skin Cosmeceuticals.

Dr. Gaetano Zanelli, Medical and Aesthetic DermatologistDr. Zanelli is a Dermatologist and Dermatologic Surgeon who has been boarded three times by the American Board of Dermatology. He received his M.D. degree with highest honors from the University of Pennsylvania and has maintained a very busy private practice in San Francisco since 1995. Dr. Zanelli has twice been honored as one of America’s Top Dermatologists by Consumers Research Council of America. He is an expert in anti-aging and rejuvenation techniques, having been among the first to use Botox, hyaluronic gel fillers, and lasers in the 1990s.

The Z Skin Center is a full-service facility for medical and aesthetic dermatology in Pacific Heights in San Francisco. All procedures at the Center are performed by board-certified dermatologist Gaetano Zanelli, not by a nurse or other practitioner. Our state-of-the-art techniques include surgical and laser procedures, injectables for facial rejuvenation and contouring, chemical peels, and neuromodulator injections (Botox and Dysport). Visit us at or call us for an appointment at 415. 923. 3600.